The **Children’s Hospital of Philadelphia (CHOP)**, founded in 1855, is the United States' first hospital dedicated exclusively to pediatric care and remains a global leader in child health. It originated to address the high child mortality from infectious diseases in Philadelphia, inspired by England’s Great Ormond Street Hospital. Over time, CHOP has expanded through several relocations, with its current state-of-the-art facility adjacent to the University of Pennsylvania campus since 1967[1][2][3]. CHOP is renowned for pioneering breakthroughs in pediatric medicine, including developing the first whooping cough (pertussis) vaccine and opening the United States’ first pediatric intensive care unit in 1967. The hospital has a strong research component, embodied in the Children's Hospital of Philadelphia Research Institute, one of the largest pediatric research centers nationally, driving innovations in genetics, cancer, neonatology, fetal surgery, and vaccine development[1][3][6]. CHOP's affiliation with the University of Pennsylvania School of Medicine since 1919 has reinforced its role as a leader in medical education and research[1][4]. Currently, CHOP operates the largest pediatric healthcare network in the U.S., with over 50 pediatrician offices and specialty centers across Pennsylvania and New Jersey. Its care model integrates family-centered, high-quality clinical services with cutting-edge research and professional education, aiming to solve complex pediatric health challenges globally[3][6]. The hospital consistently ranks among the best children's hospitals nationally and internationally, recognized for nursing excellence, clinical outcomes, and workplace culture[6]. Notably, CHOP’s leadership history includes visionary physician-in-chiefs who advanced pediatric medicine and hospital expansion, such as Drs. John Claxton Gittings, Joseph Stokes Jr., and Alan R. Cohen. Their legacies continue to shape CHOP’s commitment to clinical excellence and innovation[4]. In summary, CHOP combines a rich history, groundbreaking research, and comprehensive clinical care to maintain it